Edna C Hardeman Selected Research

Tropomyosin

1/2022	Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell-substrate adhesion in cancer cells and mechanosensitivity of cell proliferation.
1/2021	Targeting the actin/tropomyosin cytoskeleton in epithelial ovarian cancer reveals multiple mechanisms of synergy with anti-microtubule agents.
1/2020	Drug Targeting the Actin Cytoskeleton Potentiates the Cytotoxicity of Low Dose Vincristine by Abrogating Actin-Mediated Repair of Spindle Defects.
1/2019	Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1.
1/2018	On-target action of anti-tropomyosin drugs regulates glucose metabolism.
1/2017	Identification of Cancer-Targeted Tropomyosin Inhibitors and Their Synergy with Microtubule Drugs.
1/2016	A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics.
7/2015	Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments.
8/2013	A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells.
1/2008	Tropomyosins in skeletal muscle diseases.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Edna C Hardeman Research Topics

Disease

10	Neoplasms (Cancer) 01/2022 - 08/2013
6	Nemaline Myopathies (Nemaline Myopathy) 05/2016 - 01/2005
4	Muscular Diseases (Myopathy) 12/2014 - 08/2004
3	Williams Syndrome (Williams-Beuren Syndrome) 01/2016 - 02/2010
3	Muscle Weakness 12/2011 - 01/2005
2	Atrophy 05/2016 - 01/2008
2	Hypertrophy 01/2016 - 12/2011
2	Muscular Dystrophies (Muscular Dystrophy) 01/2014 - 08/2004
1	Ovarian Epithelial Carcinoma 01/2021
1	Choristoma (Ectopic Tissue) 01/2021
1	Ovarian Neoplasms (Ovarian Cancer) 01/2021
1	Insulin Resistance 01/2020
1	Hemorrhage 03/2017
1	Neuroblastoma 01/2017
1	Weight Loss (Weight Reduction) 01/2017
1	Disease Progression 01/2016
1	Craniofacial Abnormalities 06/2015
1	Fibrosis (Cirrhosis) 03/2013
1	Body Weight (Weight, Body) 03/2012
1	Congenital Abnormalities (Deformity) 03/2012
1	Hyperplasia 03/2012
1	Supravalvular Aortic Stenosis (Aortic Supravalvular Stenosis) 02/2010
1	Fatigue 04/2008
1	Arthrogryposis 01/2008
1	Congenital Structural Myopathies (Centronuclear Myopathy) 01/2008
1	Cap Myopathy 01/2008
1	Edema (Dropsy) 08/2006
1	Reperfusion Injury 08/2006

Drug/Important Bio-Agent (IBA)

12	TropomyosinIBA 01/2022 - 08/2004
7	Proteins (Proteins, Gene)FDA Link 03/2017 - 01/2005
4	Protein Isoforms (Isoforms)IBA 01/2019 - 01/2005
3	Pharmaceutical PreparationsIBA 01/2017 - 01/2016
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2021
1	Vinorelbine (Navelbine)FDA LinkGeneric 01/2021
1	CardiotoxinsIBA 01/2021
1	LipidsIBA 01/2020
1	Vinca AlkaloidsIBA 01/2020
1	AlkaloidsIBA 01/2017
1	Vincristine (Oncovin)FDA LinkGeneric 01/2017
1	taxaneIBA 01/2017
1	Myosins (Myosin)IBA 05/2016
1	Cadherins (E-Cadherin)IBA 01/2016
1	MyostatinIBA 01/2016
1	RNA (Ribonucleic Acid)IBA 01/2016
1	Activins (Activin)IBA 01/2016
1	Transcription Factors (Transcription Factor)IBA 06/2015
1	notexinIBA 03/2013
1	CorticosteroneIBA 03/2012
1	Tyrosine (L-Tyrosine)FDA Link 12/2011
1	DNA (Deoxyribonucleic Acid)IBA 02/2010
1	ElastinIBA 02/2010
1	EnzymesIBA 04/2008
1	Aquaporins (Water Channels)IBA 08/2006

Therapy/Procedure

3	Therapeutics 01/2014 - 01/2008
1	Cardiopulmonary Bypass (Heart-Lung Bypass) 08/2006